HTML is enough
Most sites do not need a framework. Semantic markup, a few styles, and a working contact link already get you further than another build step.
CSS without the kit
A border, some spacing, and a readable type scale go a long way. Skip the utility soup and write the handful of rules your page actually uses.
The importance of Web Fundamentals
A few weeks ago another webdesigner had to implement one of my vanilla html homepage designs into an existing Wordpress site. She then mailed me that she had trouble implementing my design in Wordpress because according to her "I was using a different kind of programming".